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It is now recognised that in addition to the role as procoagulant activator, tissue factor (CD 142) participates in many tumor-related processes that contribute to malignant disease progression. Joanne Bluff reviewed the different aspects supporting a role for tissue factor in tumor hemostasis, angiogenesis, metastasis and malignant cell survival [Bluff et al., 2008].
The interaction between the tissue factor pathway and cancer biology is complex. For example, it was found in ovarian cancer patients that those patients with the highest circulating tissue factor concentration had worse survival, but that this could not be explained by a higher rate of death from thromoboembolism [Han et al., 2006]. Recently, Langer and colleagues studied preoperative plasma TF antigen in a cohort of patients with localized prostate cancer. TF antigen levels were found to correlate with platelet activation in vivo and may indicate an increased risk for recurrent disease [Langer et al., 2007].
American Diagnostica provides a comprehensive range of products for research use and for clinical studies on tissue factor and its related molecules, such as factor VII and tissue factor pathway inhibitor. A list of these products and more information can be found here.
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